Whether to use My Location or POI

[civex]

I have an iQue M3, and I can set Locations on it from the touch screen, and I can also use Points of Interest, although they apparently must be entered on the POI utility on my PC. Aside from the convenience of entry, is there an advantage of one over the other? I'm not really sure why there are two modes of having waypoints on the device.

Any suggestions or clues?